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Mixing Systems -
PreValidation Service |
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By
combining support from our mixing specialists, our
comprehensive toolbox of mixing solutions and a
range of trial options in a new service package,
Millipore now offers you a unique opportunity to
help optimize your mixing process and achieve
cost-effective results.
The Right
Mix
Designed to Save You Time & Worries
Our
PreValidation service package is built upon mixing
knowledge accumulated by placing more than 10,000
NovAseptic® Mixers on the market. This success has
been accomplished with one clear mission: ensuring
that our customers obtain the mixing results they
require. High mixing efficiency, excellent quality
and unique CIP/SIP characteristics have established
us as the leading supplier of magnetically coupled,
bottom mounted mixers.
Evaluating different mixing solutions in trials
prior to specifying a process reduces the risk of
unpleasant – and potentially costly - surprises. By
investing in the new PreValidation service package
from Millipore you can save time and costs by
identifying the most efficient and reliable option
early in the decision making process.
The PreValidation
service package not only enables you to evaluate our
wide portfolio of mixing solutions while designing
your process, but will also allow you to benefit
from the support and guidance of our experts. In
addition,
we offer training programs, new product
demonstrations, troubleshooting and general
technical support.
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Press Release -
Millipore Introduces New Service
Offer for Evaluating Mixer
Solutions
Billerica, Massachusetts -
March 31, 2008
Millipore Corporation, a Life
Science leader providing
technologies, tools and services
for bioscience research and
biopharmaceutical manufacturing,
today announced the introduction
of a new service designed as a
flexible toolbox to help
customers find the most
efficient solution for their
specific mixing applications. |
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Millipore's PreValidation
Service package combines the
experience of our application
specialists with an extensive
portfolio of test equipment
enabling simulations of full
scale mixing processes.
The PreValidation Center outside
Gothenburg, Sweden and the
Bioprocess Manufacturing
Sciences Group lab in Billerica,
MA, |
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facilitate comparative studies,
particle downsizing and
emulsification efficiency trails
as well as optimization of
mixing efficiency and suspension
of solids. Our mixing
specialists can help customers
upscale or downscale their
manufacturing processes.
In addition to working at our
service centers, Millipore can
conduct on-site trials using a
range of portable test
equipment. The modularized
concept makes this a convenient
alternative for evaluations of
new mixing technologies, low
shear mixers, upstream mixers
and high shear mixers in a real
production environment.
Our mixing specialists are
available for trail support and
guidance. |
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PreValidation Center - Obtain a specific
mixing result in a challenging application
Our PreValidation Center in Sweden is equipped with
a wide range of mixers optimized for specific unit
operations, test vessels up to 5000L, and steam
facilities that enable us to offer flexible trial
packages. These packages allow you to simulate your
mixing process so you can identify how best to
perform the job.
The Bioprocess Manufacturing Sciences Group (BMSG)
in Billerica, MA, comprises a laboratory that
enables simulation of full-scale bioprocess
operations. The facility supports all NovAseptic
products and serves as an alternative location for
PreValidation services for customers in North
America.The trial portfolio
includes comparative studies, particle downsizing,
emulsification efficiency as well as optimization of
mixing efficiency and suspension of solids. Mixer
selection tools and prediction models are frequently
used by our experts. |
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PreValidation On-Site Trials - A convenient way to
optimize an existing process |
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This is your simplest alternative for evaluating
mixing solutions in an existing process. A toolbox
of mobile mixing solutions - including mobile
transparent tanks, high-shear mixers, upstream
mixers and GMP mixers - is at your disposal. This
provides you with the flexibility to evaluate new
mixing technologies in your production environment
and even in your process, if required. When
considering retrofitting an existing process for a
new mixing purpose or building multi-product
capability, our modularized product platforms make
on-site trials easy. Our experienced staff of
application experts is available for support in the
trials.
Avoid
Costly Surprises
A challenging mixing process: high amounts of
floating powder added to low levels of liquid was
evaluated in the PreValidation Center. The best
solution for optimal drainability and mixing was
found to be a combination of a tulip shaped tank and
a NovAseptic GMP Mixer. The best design of the
vessel, positioning of the mixer, point of addition
of the powder as well as selection of the required
mixer size were all captured in the design process,
before capital investments.Get it right from the start by identifying the best
solution early in the design process. Your also have
the option of evaluating a new mixing technology
on-site before installing it in your process. |
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Save
Time
Simulations in the PreValidation Center have shown
that by selecting the appropriate mixer solution,
the total mixing time can be reduced by as much as
several hours, for example, in buffer preparation
processes.
Investing in trials that help you determine the most
effective solution in terms of cleanability and
mixing saves time – time that can be used to
increase your production.
Benefit
from Fexibility
Minimum batch sizes were the limiting factor when a
customer was designing a new mixing process in
existing vessels. Trials performed at Millipore
showed that combining a high shear mixer (HS) and a
low shear mixer (GMP) allowed batch sizes even
smaller than requested. The HS dissolves the powder,
the GMP provides mixing. These findings mean the
vessels can be used for making several products – an
investment in flexibility.
Several mixer solution options and parameters can be
included in tailor made trials. You can choose
whether these take place in our PreValidation Center
or on-site at your facility. We will work with you
to design trials to help determine what mixing
solution will achieve your desired performance
results. |
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Mixing
Test in PreValidation Center
VESSEL OPTIONS:
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Material |
Tank Diameter (mm) |
Total Volume (L) |
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Stainless Steel |
1600 |
5400 |
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Stainless Steel - Tulip |
1415 |
1560 |
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Acrylic |
1200 |
1200 & 2225 |
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Acrylic |
990 |
865 & 1635 |
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Acrylic |
790 |
670 |
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Acrylic |
644 |
300 |
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Stainless Steel |
620 |
180 |
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Acrylic |
394 |
85 |
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Acrylic |
250 |
40 |
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Acrylic |
150 |
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MIXER OPTIONS: Complete
GMP, HS, HSI & USM series. |
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Mixing
Test run by Millipore at the Customer Site
VESSEL OPTIONS:
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Material |
Tank Diameter (mm) |
Total Volume (L) |
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Stainless Steel |
1600 |
5400 |
MIXER OPTIONS: GMP500,
HS T60 & USM T60 series.
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Customer
Rent Test Equipment:
Contact STI Technical Services
for details. |
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